Thanu's production Enna Solla Pogiray in 2001, but the project was later dropped.
Early in her career, she insisted on being known by her full name to avoid confusion with another actress, Gayatri Jayaraman, who was also active in the period. Gayathri Raghuram started acting at the age of fourteen. Thirumavalavan's statement on Manusmriti. On October 26, 2020, Raguram was permanently suspended from social media platform Twitter for violating Twitter's rules after posting a series of tweets relating to the controversy over VCK leader Thol. This incident drew strong criticism from BJP party cadres. Gayathri however claimed it was fake news. A case under Section 185 of the Motor Vehicles Act was filed on her and she was also fined for the incident. A police officer later drove her to her house in Adyar and confiscated her car. Police reported that she left a party at a star hotel in MRC Nagar organized for film personalities and was on her way home when she was intercepted by the police, she admitted that she had drunk alcohol when she was asked to blow into the breathing analyzer. Gayathri was booked for drunk and driving in November 2019 by Abhiramapuram Traffic Control Police. The divorce was subsequently granted in 2010. In 2008, Gayathri filed for divorce on the grounds of domestic abuse from Deepak and his parents. In August 2006, Gayathri had an arranged marriage with US-based software engineer Deepak Chandrasekar in California, and the pair subsequently held a Hindu ceremony in December 2006 which was attended by several actors and politicians from Tamil Nadu. Her mother, Girija comes from a family of choreographers, which includes Brinda and Kala. She is the great granddaughter of director Krishnaswami Subrahmanyam. Her elder sister Suja is a prominent dancer, who has also previously worked as an actress. Gayathri was born in a Iyer family as the second daughter to dance choreographers Raghuram and Girija Raghuram.